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the notion that solid tumors comprise a subset of cancer stem cells (cscs) with dysregulated self-renewal and excessive symmetric cell divisions has led to numerous studies aimed to elucidate the mechanisms regulating acd under steady-state conditions, during stem-cell expansion and in cancer. unlike normal stem cells, cscs have lost the ability to control their mode of cell division, resulting in continual excessive symmetric cell divisions and consequential uncontrolled tumor growth (figure (figure11). one of the most intriguing types of asymmetry during acd is the active segregation of the “older” template dna strands specifically to one daughter cell and the shunting of the newly synthesized dna strands to the other. recently, p53 was found to function in the maintenance of a stem cell state. given the central role of p53 in normal stem cell self-renewal, and the conjecture that cancer is a disease of excessive self-renewal, it stands to reason that p53 mutations may induce excessive self-renewal of cscs.
why then would stem cells symmetrically self-renew and risk passing replication errors off to the daughter stem cells during a time of rapid cell cycling? we would be remiss to discuss the central role of p53 in stem cell acd without mentioning p53 isoforms. it would be intriguing to test if specific p53 isoforms are involved in the regulation acd or co-segregation of template dna strands. wnt signaling is a key stem cell signaling pathway implicated in self-renewal of both normal stem cells and cscs, as well as epithelial–mesenchymal transition in cancer (40). consistent with the notion that the immortal dna strand hypothesis does not fully capture why stem cells asymmetrically segregate their template dna, there has been increasing evidence that the mother cell controls gene expression in the daughter cells through asymmetric segregation of epigenetic marks. elucidating why and how template dna strands are co-segregated is a fundamental aim in basic and translational science that spans many disciplines, and the implications could be profound.
download cell division powerpoint templates (ppt) and google slides themes to create awesome presentations. expandcell division terms (expand to view). meiosis | mitosis. anaphase – ( greek, ana = up, again) asymmetric cell division and template dna co-segregation in cancer stem cells. sharon r. pine and , cell ppt template free download, cell ppt template free download, cell biology powerpoint templates free download, cell division google slides, bio slide template.
the events involved in cell division are the division of the nucleus, cytoplasm and then the what is the difference between mitosis and meiosis? use this mind map on cell division created with imindq to an editable template is provided for you to customize your own cards! please click the preview for a closer look , free human biology powerpoint templates, molecular biology powerpoint templates free download, molecular biology powerpoint templates free download, ppt download, mitosis
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